Anti-HSP70 Monoclonal Antibody
應(yīng)用 WB IF
稀釋比例WB 1:1000-2000. IF 1:100-200.
交叉反應(yīng)Human Mouse Rat

產(chǎn)品型號：K200048M

更新時間：2022-08-15

廠商性質(zhì)：生產(chǎn)廠家

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Anti-HSP70 Monoclonal Antibody

英文名稱	Anti-HSP70 Monoclonal Antibody
宿主	Mouse
別名	heat shock protein 70
應(yīng)用	WB IF
稀釋比例	WB 1:1000-2000. IF 1:100-200.
交叉反應(yīng)	Human Mouse Rat
蛋白分子量	70kDa
Gene ID	3303/3304
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG1
免疫原	A synthetic peptide coupled to KLH
性狀	液體
Public Immunogen Range	A synthetic peptide coupled to KLH
Subcellular Locations	Cytoplasm
Swiss Prot	P0DMV8/P0DMV9
克隆號	3G10
克隆類型	Monoclonal Antibody
背景資料	The 70 kilodalton heat shock proteins (Hsp70s) are a family of ubiquitously expressed heat shock proteins. Proteins with similar structure exist in virtually all living organisms. The Hsp70s are an important part of the cell's machinery for protein folding, and help to protect cells from stress. Hsp70 is usually in an ATP bound state. Hsp70 by itself is characterized by a very weak ATPase activity, such that spontaneous hydrolysis will not occur for many minutes. As newly synthesized proteins emerge from the ribosomes, the substrate binding domain of Hsp70 recognizes sequences of hydrophobic amino acid residues, and interacts with them. This spontaneous interaction is reversible, and in the ATP bound state Hsp70 may relatively freely bind and release peptides. However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis.